Organized by:

World Federation of Societies for Chronobiology (WFSC)
Chinese Society for Biological Rhythms (CSCB-CSBR)
Soochow University
Aschoff-Honma Foundation
National Institute of Biological Science
Chinese Sleep Research Society

V World Congress of Chronobiology

Suzhou, China. April 25-27, 2019



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Wednesday April 24, 2019
09:00-18:00 Registration
18:00-21:00 Welcome Party
Thursday April 25, 2019
08:00-08:15 Opening address (Ying Xu and Till Roenneberg)
08:15-09:45 Keynote Lectures I
Chair: Sato Honma (Hokkaido U)
08:15-09:00 Keynote Lecture I: Ying-Hui Fu (UCSF) Molecular Investigation of Human Sleep Behavior
09:00-09:45 Keynote Lecture II: Shuji Akiyama (Jpn Inst. of Mol. Sci.) Cyanobacterial circadian clock system through the chemistry of rhythm, structure, and evolutionary diversity
09:45-10:00 Coffee Break
10:00-11:30 Keynote Lectures II
Chair: Eric Zhang (Nat'l. Inst. Biol. Sci., Beijing)
10:00-10:45 Keynote Lecture III: Amita Sehgal (U Pennsylvania) Using a small animal model to understand how and why we sleep
10:45-11:30 Keynote Lecture IV: Charlotte Helfrich-Forster (U Würzburg) The neuropeptide “Pigment-Dispersing Factor” in the circadian clock of fruit flies and other insects
11:30-13:30 Lunch Box and Posters
13:30-15:30 Symposium 1 – Mechanisms Underlying Sleep Controls
Co-Chairs: Hiroki Ueda (U Tokyo);Qinghua Liu (Nat'l. Inst. Biol. Sci., Beijing )
13:30-14:00 Hiroki Ueda (U Tokyo, Japan) Organism-level Systems Biology by Next-generation Genetics and Whole-organ Cell Profiling
14:00-14:25 Zhi-li Huang (Fudan) TBD
14:25-14:50 Qinghua Liu (Nat'l. Inst. Biol. Sci., Beijing ) Quantitative phosphoproteomic analysis of the molecular substrates of homeostatic sleep need
14:50-15:15 Chunghun Lim (Ulsan Nat'l. Inst. Sci.&Tec.) Metabolic control of sleep: amino acid metabolism and adaptive sleep behaviors in Drosophila
15:15-15:30 Kazuhiko Kume (Nagoya City U) Crosstalk of circadian rhythm and sleep regulation in Drosophila
13:30-15:45 Symposium 2 – Translational Chronobiology
Co-Chairs: John Hogenesch (Cinti. Chd's Hosp.); Nicolas Cermakian (McGill U)
13:30-14:00 John Hogenesch (Cinti. Chd's Hosp.) Time for circadian medicine
14:00-14:30 Nicolas Cermakian (McGill U) Effect of night shift work and of bright light treatment on the human central and peripheral clocks, circadian transcriptome and immune circadian rhythms
14:30-15:00 Masao Doi (Kyoto U) Time-restricted G-protein signaling through Gpr176/Gz/Rgs16 sets the pace of the central clock
15:00-15:15 Ningning Wang (Nanjing Med. U) Effects of Parathyroidectomy on Nocturnal Non-dipping Heart Rate in Stage 5 Chronic Kidney Disease Patients
15:15-15:30 DingJun Cai (Chendu U of Trad. Chin. Med.) The SCN phosphoproteome mechanism of acupuncture on circadian rhythm at different time
15:30-15:45 Coffee Break
15:45-17:45 Symposium 3 – New Insights Into Clock Input: from Retina to SCN
Co-Chairs: Erik Herzog (Washington U St. Louis); Sato Honma (Hokkaido U)
15:45-16:15 Erik Herzog (WUSTL, USA) Clock cartography: Mapping functional connections in the SCN
16:15-16:45 Rae Silver (Columbia U) Anisotropy in Physical and Functional SCN Network Topologies
16:45-17:15 Rob Lucas (U Manchester) What the mammalian eye tells the mammalian SCN
17:15-17:30 Yan Jun (Shanghai Inst. NeuroSci.) Spatiotemporal single-cell analysis of mammalian circadian pacemaker
17:30-17:45 Daisuke Ono (Nagoya U) GABA in the suprachiasmatic nucleus refines circadian behavioral rhythms
15:45-17:45 Symposium 4 – Consequences of Circadian Disturbance
Co-Chairs: Diego Golombek (U Buenos Aires); Carolina Escobar (Nat'l. Autonomous U of Mexcio)
15:45-16:15 Diego Golombek (U Buenos Aires) The garden of the forking paths: Metabolic and behavioral alterations in a model of forced circadian desynchronization
16:15-16:45 Carolina Escobar (Nat'l. Autonomous U of Mexcio) Mood Disorders And Metabolic Syndrome In Animal Models For Circadian Disruption
16:45-17:15 Han Wang (Soochow U) The circadian clock promotes spermatogonial differentiation and fertilization through retinoic acid signaling
17:13-17:30 Ruud M Buijs ( Nat'l. Autonomous U of Mexcio) A spinal inflammatory reflex gated by the suprachiasmatic nucleus
17:30-17:45 Ximing Qin (Anhui U) Comparative Analysis and CRISPR/Cas9 Gene Knockout Reveal that E4BP4 Mediates Lithium Upregulation of Per2 Expression
19:00-19:30 WFC meeting
Friday April 26, 2019
08:00-10:00 Symposium 5 – Epigenetic/Transcriptional Layers Around the Clock
Co-Chairs: Eric Zhang (Nat'l. Inst. Biol. Sci., Beijing); Katja Lamia (Scripps Inst.)
08:00-08:30 Katja Lamia (Scripps Inst.) Cryptochromes impact metabolism by promiscuous transcriptional repression
08:30-09:00 Tian Xue (U Sci.&Tec. China ) A Circadian Rhythm-gated Subcortical Visual Circuit Conducts Light Signals at Night to Induce Depressive-like Behaviors
09:00-09:30 Eric Zhang (Nat'l. Inst. Biol. Sci., Beijing ) Chemical perturbation of RUVBL2 regulates the phase of the circadian clock
09:30-09:45 Gang Wu (Cinti. Chd's Hosp.) Circadian rhythms in human dermis and epidermis
09:45-10:00 Guang-zhong Wang (Chin. Acad. Sci.) A single factor dominant the behavior of rhythmic genes in mouse tissues
08:00-10:00 Symposium 6 – Molecular Regulators in Controlling Timing
Co-Chairs: Yoshitaka Fukada (U Tokyo); Jinhu Guo (Sun Yat'sen U)
08:00-08:30 Yoshitaka Fukada (U Tokyo) Roles of Ubiquitination of CRY proteins by FBXL3 and FBXL21
08:30-09:00 David Virshup (Nat'l U Singapore) CK1δ/ε regulation of the PER2 phosphoswitch
09:00-09:30 ShihKuo Chen (Nat'l. Taiwan U) The function and projection of ipRGC to the suprachiasmatic nucleus
09:30-09:45 Xiaodong Li (Wuhan U) Regulation of Pol II pausing is involved in daily gene transcription in the mouse live
09:45-10:00 Xiao Liu (U Texas Med. CTR) Molecular basis of circadian period determination and temperature compensation in Neurospora
10:00-10:15 Coffee Break
10:15-12:15 Symposium 7 – Relevance of Circadian Clock and Cognition and Performance
Co-Chairs: Horacio de la Iglesia (UW); Ruifeng Cao (UMN, USA)
10:15-10:45 Horacio de la Iglesia (U Washington) Later school start times in adolescents lead to longer sleep and are associated with better academic performance
10:45-11:15 Maria Paz Hidalgo (Clinic. Hosp. of Porto Alegre) Biológicas Rhythm: a Translational Challenge in Psychiatry
11:15-11:45 Hung-Chun Chang (Shanghai Inst. NeuroSci.) A BMAL1-ablation macaque model for circadian disorders and associated psychosis
11:45-12:00 Ruifeng Cao (U Minnesota) Autistic-like behavior and cerebellar pathology in mice lacking the circadian clock gene Bmal1
12:00-12:15 Su-xia Li (Beijing Med. U) Clock gene per1 is involved in the mechanism underlying the rapid antidepressant action of adenosine A1 receptor agonist
10:15-12:15 Symposium 8 – Interactions between the Clock and Metabolism
Co-Chairs: Yi Liu (Fudan); Zheng Sun (Baylor)
10:15-10:45 Yi Liu (Fudan U) Role of Circadian Clcok in the Regulation of mTORC1
10:45-11:15 Yiguo Wang (Tsinghua U) The Tight Junction Protein TJP1 Regulates the Feeding-modulated Hepatic Circadian Clock
11:15-11:45 Zheng Sun (Baylor Coll. Med.) Epigenomic regulation of metabolism and neurocognition by the circadian clock
11:45-12:00 Aya Honma (U Surrey) Effect of Acute Total Sleep Deprivation on Melatonin and Metabolite rhythms in Females
12:00-12:15 Meng Qu (U South Cali.) Nuclear receptor HNF4A-modulated circadian rhythms play essential roles in human health and disease
12:15-13:30 Lunch Box and Posters
13:30-14:00 AFC meeting
14:00-17:45 Social Activities and Posters
18:00-20:00 Banquet
20:00-21:00 CSBR meeting
Saturday April 27, 2019
08:00-10:00 Symposium 9 – Molecular Architecture of circadian clocks
Co-Chairs: Joanna Chiu (UC DAVIS); Yong Zhang (U Nevada)
08:00-08:30 Joanna Chiu (UC Davis) Nutrient-sensitive protein O-GlcNAcylation regulates circadian physiology
08:30-08:55 Fang Guo (Zhejiang U) Dissecting the Connection of Sleep-regulating Circadian Neurons in Flies
08:55-09:20 Donggen Luo (Peking U) Circuit organization of visual photoentrainment in Drosophila central clock
09:20-09:45 Zhangwu Zhao (China Agri. U) Sleep and circadian rhythm regulation mediated by juvenile hormone pathway in Drosophila
09:45-10:00 Yong Zhang (U Nevada) The transcription factor CREBA interacts with the ATX2/TYF complex to regulate circadian behavior
08:00-10:00 Symposium 10 – Effects of Circadian Systems On Sleep and Health
Co-Chairs: Phllis Zee (Northwestern U); Fang Han (Peking U Int'l Hosp.)
08:00-08:30 Phllis Zee (Northwestern U) Circadian Medicine: Insights from the Clinic
08:30-08:55 Fang Han (Peking U Int'l Hosp.) TBD
08:55-09:20 Hiromasa Funato (U Tsukuba) Forward genetics in mice identified novel sleep-regulating genes
09:20-09:45 Jinhu Guo (Sun Yat'sen U) The circadian rhythms under special environments
09:45-10:00 Ke Lv (China Key lab Space Med.) Light Exposure Application for Entrainment of Circadian Rhythms and Regulation of Sleep Quality
10:00-10:15 Coffee Break
10:15-12:15 Symposium 11 – Circuits Wiring the Circadian Clocks
Co-Chairs: Luis Larrondo (Ponti. Catho. U of Chile); Xiaodong Xu (Henan U)
10:15-10:45 Luis Larrondo (Ponti. Catho. U of Chile) High-Resolution Analysis of Phase Responses and Clock Dynamics Utilizing a Live Canvas and Eidetic Memory
10:45-11:15 Xiaodong Xu (Henan U) Circadian oscillators control senescence via direct regulation of organelle energy metabolism in Arabidopsis
11:15-11:45 Takato Imazumi (U Washington) Molecular Basis of Seasonal Flowering in Arabidopsis
11:45-12:00 Mian Zhou (Capital Normal U) Crosstalk between the circadian clock and plant immunity
12:00-12:15 Lei Wang (Chin. Acad. Sci.) SPINDLY Fine-tunes Arabidopsis Circadian Period through Modulating PRR5 Protein Abundance in the Nucleus
10:15-12:15 Symposium 12 – The memorial symposium of Serge Daan by Aschoff Honma Foundation
Co-Chair: Ken-ichi Honma (Hokkaido University); Ying Xu (CAM-SU)
10:15-10:45 Ken-ichi Honma (Hokkaido U) Beyond the two-process model
10:45-11:15 Roelof Hut (U Groningen) The flexible clock: adaptive responses to maximize survival and reproduction
11:15-11:45 William Schwartz (U Texas) M and E: Serge Daan’s Binary Clock
11:45-12:15 Sheeba Vasu (Jawaharlal Nehru Centre) Circadian Clock properties and their relationship with intrinsic period or tau
12:15-13:00 Lunch Box
13:00-14:45 Symposium 13 – Crosstalk Controls of Circadian Clock and Nutrition
Co-Chairs: Shigenobu Shibata (Waseda U); Chang Liu (China Pharma. U)
13:00-13:30 Shigenobu Shibata (Waseda U) Timing effect of intake of inulin and inulin containing food/ vegetables on the continuous blood glucose level, cecal short chain fatty acids and microbiota in mice and humans
13:30-14:00 Chang Liu (China Pharma. U) DNA polymerase β R137Q mutant facilitates the development of liver cancer via methylation of clock gene Per1 promoter
14:00-14:15 Juan Du (China Agri. U) Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octß2R cascade
14:15-14:30 Rosa van den Berg (Leiden U Med. Center) A diurnal rhythm in brown adipose tissue causes rapid clearance and combustion of plasma lipids at wakening
14:30-14:45 Weiqi He (Soochow U) Circadian clock regulates intestinal secretary cell differentiation
13:00-14:45 Symposium 14 – Circadian Misalignment and Diseases
Co-Chairs: Debra Skene (U Surrey); Qing-Jun Meng (U Manchester)
13:00-13:30 Debra Skene (U Surrey) Circadian Misalignment in Shift Work - Challenges
13:30-14:00 Qing-Jun Meng (U Manchester) Circadian rhythms in the musculoskeletal system: implications in health and disease
14:00-14:15 Luoying Zhang (Huazhong U Sci.&Tec.) Integrated Omics in Drosophila Uncover a Circadian Kinome
14:15-14:30 Huatao Chen (NW Agri &Fores. U) Coordination of circadian clock and androgenic signaling is required for sustaining Elovl3 rhythmic expression in mouse liver
14:30-14:45 Mengru Xie (Huazhong U Sci.&Tec.) Porphyromonas gingivalis accelerates atherosclerosis via circadian dysrhythmia
14:45-15:00 Coffee Break
15:00-17:00 Symposium 15 – Clocks in Nature: Seasonal and Field Timing
Co-Chairs: Vinod Kumar (U Delhi); Takashi Yoshimura (Nagoya U)
15:00-15:30 Vinod Kumar (U Delhi) Environmental Cues, Circadian Rhythms and Seasonal Timekeeping in Songbirds
15:30-16:00 Takashi Yoshimura (Nagoya U) Molecular basis of seasonal changes in behavior
16:00-16:15 He Wenyan (U Munich) A circadian zip code guide leukocyte homing
16:15-16:30 Sangeeta Rani (U Lucknow) Circannual rhythm in regulation of annual reproduction in subtropical spotted munia (Lonchura punctulata)
16:30-16:45 Lin Zhang (U Leicester) Molecular basis of tidal rhythms in an intertidal crustacean Eurydice pulchra
16:45-17:00 Aakansha Sharma (U Delhi) Molecular correlates of spring and autumn migration phenotypes in latitudinal migrants: Insights from gene expression studies in migratory buntings
15:00-17:00 Symposium 16 – Human Chronobiology - from Genes to Behavior
Co-Chairs: Till Roenneberg (Munich U); Elizabeth Klerman (Harvard U)
15:00-15:30 Till Roenneberg (Munich U) The power of actimetry in circadian and sleep research
15:30-16:00 Elizabeth B.Klerman (Brigham&Women Hosp., Harvard U) Applying mathematical modeling of the effects of light on the human circadian pacemaker to interpretation of experimental results
16:00-16:30 Richa Saxena (Mass. Gen. Hosp., Harvard U) Chronotype in Health and Disease: Insights from population-scale genetics
16:30-16:45 Gaggioni G (U Liege) EEG neuronal response complexity circadian rhythm in young and older individuals
16:45-17:00 Yanyun Ding (Yijishan Hosp. Wannan Med. Coll.) Combined effects of melatonin and valsartan in the treatment of spontaneous hypertension rats with non-dipping blood pressure patter via circadian mechanism
17:00-17:45 Keynote Lecture III
Chair: Luoying Zhang (Huazhong U Sci.&Tec.)
17:00-17:45 Keynote Lecture V:Minmin Luo (Chin. Inst. Brain Res./Nat'l. Inst. Biol. Sci., Beijing) Reward processing by the Dorsal Raphe
17:45-18:00 Awards: By Ken-ichi Honma (Hokkaido U), Xiang Gao (Nanjing U)
Closing Remarks: By Ken-ichi Honma (Hokkaido U)
Sunday April 28, 2019
08:30-17:00 Circadain Clock training Course
Lecturers: Jinghuo Guo & Gang Wu

Copyright©2019 CSBR: Chinese Society for Biological Rhythms